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Can I read Mitochondria-driven Elimination of Cancer and Senescent Cells on EtoBox?
Mitochondria-driven Elimination of Cancer and Senescent Cells by Sona Hubackova; Silvia Magalhaes Novais; Eliska Davidova; Jiri Neuzil; Jakub Rohlena is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Mitochondria-driven Elimination of Cancer and Senescent Cells about?
## Abstract Mitochondria and oxidative phosphorylation (OXPHOS) are emerging as intriguing targets for the efficient elimination of cancer cells. The specificity of this approach is aided by the capacity of non-proliferating non-cancerous cells to withstand oxidative insult induced by OXPHOS inhibition. Recently we discovered that mitochondrial targeting can also be employed to eliminate senescent cells, where it breaks the interplay between OXPHOS and ATP transporters that appear important for the maintenance of mitochondrial morphology and viability in the senescent setting. Hence, mitochondria/OXPHOS directed pharmacological interventions show promise in several clinically-relevant scenarios that call for selective removal of cancer and senescent cells.
Who reads Mitochondria-driven Elimination of Cancer and Senescent Cells?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Sona Hubackova; Silvia Magalhaes Novais; Eliska Davidova; Jiri Neuzil; Jakub Rohlena
- Publisher
- Walter de Gruyter GmbH
- Published
- 2018
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)