Opening book details…
Can I read Folate Deficiency, Mismatch Repair-dependent Apoptosis, and Human Disease on EtoBox?
Folate Deficiency, Mismatch Repair-dependent Apoptosis, and Human Disease by Guo-Min Li; Steven R. Presnell; Liya Gu is a Medicine article available to read on EtoBox.
What is Folate Deficiency, Mismatch Repair-dependent Apoptosis, and Human Disease about?
The vitamin that is most commonly deficient in the American diet is folate. Severe folate deficiency in humans is known to cause megaloblastic anemia and developmental defects, and is associated with an increased incidence of several forms of human cancer. Although the exact mechanisms by which this vitamin deficiency may cause these diseases are not known at the present time, recent work has shown that folate deficiency also causes genomic instability and programmed cell death (or apoptosis). Additionally, it is known that the DNA mismatch repair pathway mediates folate deficiency-induced apoptosis. This review will first describe work suggesting that folate deficiency causes genomic instability and apoptosis, then discuss possible mechanisms by which the mismatch repair pathway could trigger folate deficiency-induced apoptosis, which has either protective or destructive effects on tissue.
Who reads Folate Deficiency, Mismatch Repair-dependent Apoptosis, and Human Disease?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Guo-Min Li; Steven R. Presnell; Liya Gu
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0955-2863)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)