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NALCN is a unique ion channel that functions as a sensor for sodium and calcium ions, exhibiting variable selectivity based on its structural features. Its adaptable pore can resemble either calcium-like or sodium-like selectivity filters, depending on the animal lineage, and it has been implicated in various physiological processes. The document discusses the evolutionary history, structural characteristics, and functional implications of NALCN, highlighting its role in ion conductance and cellular excitab

Author

Ricardo Quinteiro

Language

EN