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The study investigates the development of a pulsatile-release chronotherapeutic drug delivery system for montelukast sodium, aimed at treating nocturnal asthma by synchronizing drug release with circadian rhythms. Eight different press-coated tablet formulations were created, varying in outer shell composition and particle size to achieve the desired lag-time before drug release. The findings suggest that specific formulations can effectively deliver montelukast during peak asthma incidents occurring in the

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qtppcqa

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EN