About this Medicine article
Approach to eradication of initial Pseudomonas aeruginosa infection in children with cystic fibrosis by Miriam M. Treggiari; Margaret Rosenfeld; George Retsch-Bogart; Ron Gibson; Bonnie Ramsey is a Medicine article available to read on EtoBox.
## Abstract The primary cause of morbidity and mortality in children with cystic fibrosis (CF) is the progression of obstructive lung disease secondary to chronic endobronchial infection, mainly caused by __Pseudomonas aeruginosa__ (__Pa__). Initial __Pa__ isolates are typically non‐mucoid, usually susceptible to most anti‐pseudomonal antibiotics, and potentially amenable to eradication. Preliminary studies of early intervention suggest a “window of opportunity” with anti‐pseudomonal antibiotics to eradicate __Pa__ from upper and lower airways. Several large trials in young children with CF are currently ongoing with the goals of (1) investigating if early intervention at the time of initial __Pa__ acquisition is effective and safe and (2) identifying the least invasive and safest treatment regimen to achieve both microbiologic and clinical benefits. Pediatr Pulmonol. 2007; 42:751–756. © 2007 Wiley‐Liss, Inc.
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- Author
- Miriam M. Treggiari; Margaret Rosenfeld; George Retsch-Bogart; Ron Gibson; Bonnie Ramsey
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 8755-6863)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)