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Oral Microbial Communities in 5-Year-old Children with Versus Without Dental Caries by Zhengyan Yang; Ting Cai; Yueheng Li; Dan Jiang; Jun Luo; Zhi Zhou is a Dentistry article available to read on EtoBox.

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## Background Caries in young children has received more and more attention. The study of the oral microbiota may help to understand the polymicrobial etiology of dental caries. ## Objectives To investigate the diversity and structure of microbial communities in saliva samples from 5-year-old children with versus without dental caries. ## Methods A total of 36 saliva samples were collected from 18 children with high caries (HB group) and from 18 children without caries (NB group). Then, 16S rDNA was amplified from bacterial samples using polymerase chain reaction, and high-throughput sequencing was performed using Illumina Novaseq platforms. ## Results Sequences were clustered into operational taxonomic units (OTUs), which were distributed among 16 phyla, 26 classes, 56 orders, 93 families, 173 genera, and 218 species. __Firmicutes, Bacteroides, Proteobacteria, Actinobacteria, Fusobacteria__, __Patescibacteria, Epsilonbacteraeota, Cyanobacteria, Acidobacteria__ and __Spirochaetes__ were basically the same in different groups, but their relative abundances were different. The core microbiome was defined as the species from 218 shared microbial taxa. The alpha diversity test showed t

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Author

Zhengyan Yang; Ting Cai; Yueheng Li; Dan Jiang; Jun Luo; Zhi Zhou

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Dentistry (Health Sciences)