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Metabolomics Profiling and Diagnosis Biomarkers Searching for Drug-Induced Liver Injury Implicated to Polygonum multiflorum: A Cross-Sectional Cohort Study by Huang, Ying; Zhao, Xu; Zhang, Zi-teng; Chen, Shuai-shuai; Li, Shan-shan; Shi, Zhuo; Jing, Jing; Huang, Ang; Guo, Yu-ming; Bai, Zhao-fang; Zou, Zheng-sheng; Xiao, Xiao-he; Wang, Jia-bo; Niu, Ming is a Medicine article available to read on EtoBox.
What is Metabolomics Profiling and Diagnosis Biomarkers Searching for Drug-Induced Liver Injury Implicated to Polygonum multiflorum: A Cross-Sectional Cohort Study about?
Aim:The diagnosis of drug-induced liver injury (DILI) remains a challenge and the cases ofPolygonum multiflorumThunb. (PM) induced DILI (PM-DILI) have received much attention This study aimed to identify a simple and high-efficiency approach to PM-DILI diagnosis via metabolomics analysis. Methods:Plasma metabolites in 13 PM-DILI patients were profiled by liquid chromatography along with high-resolution mass spectrometry. Meanwhile, the metabolic characteristics of the PM-DILI were compared with that of autoimmune hepatitis (AIH), hepatitis B (HBV), and healthy volunteers. Results:Twenty-four metabolites were identified to present significantly different levels in PM-DILI patients compared with HBV and AIH groups. These metabolites were enriched into glucose, amino acids, and sphingolipids metabolisms. Among these essential metabolites, the ratios of P-cresol sulfate vs. phenylalanine and inosine vs. bilirubin were further selected using a stepwise decision tree to construct a classification model in order to differentiate PM-DILI from HBV and AIH. The model was highly effective with sensitivity of 92.3% and specificity of 88.9%. Conclusions:This study presents an integrated view of
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- Author
- Huang, Ying; Zhao, Xu; Zhang, Zi-teng; Chen, Shuai-shuai; Li, Shan-shan; Shi, Zhuo; Jing, Jing; Huang, Ang; Guo, Yu-ming; Bai, Zhao-fang; Zou, Zheng-sheng; Xiao, Xiao-he; Wang, Jia-bo; Niu, Ming
- Publisher
- Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2014- (ISSN 2296-858X)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)