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Can I read Three-dimension Chitosan Hydrogel Loading Melanin Composite Nanoparticles for Wound Healing by Anti-bacteria, Immune Activation and Macrophage Autophagy Promotion on EtoBox?
Three-dimension Chitosan Hydrogel Loading Melanin Composite Nanoparticles for Wound Healing by Anti-bacteria, Immune Activation and Macrophage Autophagy Promotion by Xiaoying Kong; Haoyu Chen; Fuqiang Li; Fenglan Zhang; Yuping Jiang; Junyao Song; Yuanliang Sun; Bin Zhao; Jinsheng Shi is a Materials Science article available to read on EtoBox.
What is Three-dimension Chitosan Hydrogel Loading Melanin Composite Nanoparticles for Wound Healing by Anti-bacteria, Immune Activation and Macrophage Autophagy Promotion about?
Application of Combined photodynamic therapy (PDT) and photothermal therapy (PTT) has become one of the most promising strategy to replace antibiotics and avoid the epidemic of drug-resistant strains during wound healing. However, high amount of reactive oxygen species (ROS) and high temperature cause severe stress response to normal tissues, leading to potential risks of wound healing. Herein, a three-dimension chitosan hydrogel melanin-glycine-C60 nanoparticles (MGC NPs) were prepared to realized effective anti-bacterial activity, immune activation and macrophage autophagy promotion in three-dimensional wound space without triggering stress response. MGC NP is a composite polymer material composed of natural melanin polymer, oligopeptide and carbon-based material, which showed excellent biological safety. By regulating the peptide length between melanin and C60 and nanoparticle content, a high ROS/heat environment at the upper wound site and a low ROS/heat environment at the lower region adjacent to the wound tissue were established to obtain a three-dimension hydrogel with precise PDT and PTT efficiency in different regions. Highly effective PDT/PTT was used to kill microorganis
Who reads Three-dimension Chitosan Hydrogel Loading Melanin Composite Nanoparticles for Wound Healing by Anti-bacteria, Immune Activation and Macrophage Autophagy Promotion?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Xiaoying Kong; Haoyu Chen; Fuqiang Li; Fenglan Zhang; Yuping Jiang; Junyao Song; Yuanliang Sun; Bin Zhao; Jinsheng Shi
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Materials Science (Physical Sciences)