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New Glycosidic Derivatives of Histidine-containing Dipeptides with Antioxidant Properties and Resistant to Carnosinase Activity by Francesco Bellia; Angela Maria Amorini; Diego La Mendola; Graziella Vecchio; Barbara Tavazzi; Bruno Giardina; Valentina Di Pietro; Giuseppe Lazzarino; Enrico Rizzarelli is a Chemistry article available to read on EtoBox.
What is New Glycosidic Derivatives of Histidine-containing Dipeptides with Antioxidant Properties and Resistant to Carnosinase Activity about?
Synthesis, antioxidant properties and resistance to carnosinase hydrolysis of histidine-containing dipeptides are reported in this study. Carnosine (b-alanyl-L-histidine), homocarnosine (g-aminobutyryl-L-histidine) and anserine (b-alanyl-3-methyl-L-histidine) were covalently derivatized with b-cyclodextrin to form different OH-or NH-bound conjugates. Mass spectroscopic and 1 H NMR data were used to determine the structure and the purity of the various b-cyclodextrin derivatives. The inhibitory effect towards oxidation of human LDL induced by Cu 2þ ions, was estimated by measuring malondialdehyde formation as a function of increasing concentrations of these newly synthesized compounds (the b-cyclodextrin-anserine conjugated in 3 had the highest antioxidant effect). All derivatives had higher antioxidant effects than those of the corresponding free histidine-containing dipeptides. Resistance to rat brain carnosinase hydrolysis of the most active derivatives indicated that these compounds are good candidates for further studies in more complex cellular and animal models. Their possible applications for remedies in neurodegenerative disorders, such as Alzheimer's and Parkinson's diseas
Who reads New Glycosidic Derivatives of Histidine-containing Dipeptides with Antioxidant Properties and Resistant to Carnosinase Activity?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Francesco Bellia; Angela Maria Amorini; Diego La Mendola; Graziella Vecchio; Barbara Tavazzi; Bruno Giardina; Valentina Di Pietro; Giuseppe Lazzarino; Enrico Rizzarelli
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0223-5234)
- Published
- 2008
- Language
- EN
- Field
- Chemistry (Physical Sciences)