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Can I read Myxovirus-1 and protein kinase haplotypes and fibrosis in chronic hepatitis C virus on EtoBox?
Myxovirus-1 and protein kinase haplotypes and fibrosis in chronic hepatitis C virus by Leland J. Yee; Yong-Ming Tang; David E. Kleiner; Dai Wang; KyungAh Im; Abdus Wahed; Xiaomei Tong; Shannon Rhodes; Xiaowen Su; R. Margaret Whelan; Robert J. Fontana; Marc G. Ghany; Brian Borg; T. Jake Liang; Huiying Yang; Virahep-C Study Group is a Medicine article available to read on EtoBox.
What is Myxovirus-1 and protein kinase haplotypes and fibrosis in chronic hepatitis C virus about?
for the Virahep-C Study Group ## Candidate genes, including myxovirus resistance-1 (Mx1), protein kinase (PKR), transforming growth factor-1 (TGF-), interleukin-10 (IL-10), and interferon-gamma (IFN-␥) , were evaluated for associations with liver fibrosis in 374 treatment-naive patients with genotype-1 chronic HCV infection [194 Caucasian Americans (CAs) and 180 African Americans (AAs)], using a genetic haplotype approach. Among the 18 haplotypes that occurred with a frequency >5% in the cohort overall, the Mx1- (-123C)-(؉6886A)-(؉19820G(379V))-(؉38645T) (abbreviated ## Mx1-CAGT), and PKR-(؉110T)-(؉7949G)-(؉13846A)-(؉22937T)-(؉40342T) (abbreviated PKR-TGATT) haplotypes were independently associated with less severe hepatic fibrosis (Ishak > 3 versus <3). These associations persisted after adjustment for potential confounders such as alcohol use, sex, age (which is strongly correlated with the estimated duration of HCV infection [Spearman's correlation coefficient (r s ) ؍ 0.6)], and race (for Mx1-CAGT: OR ؍ 0.33; 95% CI: 0.16-0.68; P ؍ 0.0027; and for PKR-TGATT: OR ؍ 0.56; 95% CI: 0.32-0.98; P ؍ 0.0405). Population structure was evaluated using the structured associatio
Who reads Myxovirus-1 and protein kinase haplotypes and fibrosis in chronic hepatitis C virus?
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- Author
- Leland J. Yee; Yong-Ming Tang; David E. Kleiner; Dai Wang; KyungAh Im; Abdus Wahed; Xiaomei Tong; Shannon Rhodes; Xiaowen Su; R. Margaret Whelan; Robert J. Fontana; Marc G. Ghany; Brian Borg; T. Jake Liang; Huiying Yang; Virahep-C Study Group
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)