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Radioimmunotherapy of Pancreatic Ductal Adenocarcinoma: A Review of the Current Status of Literature by Hull, Ashleigh; Li, Yanrui; Bartholomeusz, Dylan; Hsieh, William; Allen, Barry; Bezak, Eva is a Medicine article available to read on EtoBox.
What is Radioimmunotherapy of Pancreatic Ductal Adenocarcinoma: A Review of the Current Status of Literature about?
Pancreatic ductal adenocarcinoma (PDAC) has long been associated with low survival rates. A lack of accurate diagnostic tests and limited treatment options contribute to the poor prognosis of PDAC. Radioimmunotherapy using α- or β-emitting radionuclides has been identified as a potential treatment for PDAC. By harnessing the cytotoxicity of α or β particles, radioimmunotherapy may overcome the anatomic and physiological factors which traditionally make PDAC resistant to most conventional treatments. Appropriate selection of target receptors and the development of selective and cytotoxic radioimmunoconjugates are needed to achieve the desired results of radioimmunotherapy. The aim of this review is to examine the growing preclinical and clinical trial evidence regarding the application of α and β radioimmunotherapy for the treatment of PDAC. A systematic search of MEDLINE^®^ and Scopus databases was performed to identify 34 relevant studies conducted on α or β radioimmunotherapy of PDAC. Preclinical results demonstrated α and β radioimmunotherapy provided effective tumour control. Clinical studies were limited to investigating β radioimmunotherapy only. Phase I and II trials observe
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- Author
- Hull, Ashleigh; Li, Yanrui; Bartholomeusz, Dylan; Hsieh, William; Allen, Barry; Bezak, Eva
- Publisher
- MDPI AG; Multidisciplinary Digital Publishing Institute (MDPI); Basel: MDPI, 2009- (ISSN 2072-6694)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)