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Gastrointestinal Organs and Organoids-on-a-chip: Advances and Translation Into the Clinics by Mariana R Carvalho; Le-Ping Yan; Bo Li; Chang-Hua Zhang; Yu-Long He; Rui L Reis; Joaquim M Oliveira is a Engineering article available to read on EtoBox.

What is Gastrointestinal Organs and Organoids-on-a-chip: Advances and Translation Into the Clinics about?

## Abstract Microfluidic organs and organoids-on-a-chip models of human gastrointestinal systems have been established to recreate adequate microenvironments to study physiology and pathophysiology. In the effort to find more emulating systems and less costly models for drugs screening or fundamental studies, gastrointestinal system organoids-on-a-chip have arisen as promising pre-clinical __in vitro__ model. This progress has been built on the latest developments of several technologies such as bioprinting, microfluidics, and organoid research. In this review, we will focus on healthy and disease models of: human microbiome-on-a-chip and its rising correlation with gastro pathophysiology; stomach-on-a-chip; liver-on-a-chip; pancreas-on-a-chip; inflammation models, small intestine, colon and colorectal cancer organoids-on-a-chip and multi-organoids-on-a-chip. The current developments related to the design, ability to hold one or more ‘organs’ and its challenges, microfluidic features, cell sources and whether they are used to test drugs are overviewed herein. Importantly, their contribution in terms of drug development and eminent clinical translation in precision medicine field, F

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Author

Mariana R Carvalho; Le-Ping Yan; Bo Li; Chang-Hua Zhang; Yu-Long He; Rui L Reis; Joaquim M Oliveira

Publisher

IOP Publishing

Published

2023

Language

EN

Field

Engineering (Physical Sciences)