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Can I read Safety & pK of IV loading dose of lacosamide in the ICU on EtoBox?
Safety & pK of IV loading dose of lacosamide in the ICU by R. Eugene Ramsay; Vivek Sabharwal; Fawad Khan; Hina Dave; Cyrus Kafai; Rachel Shumate; Megan Irland is a Medicine article available to read on EtoBox.
What is Safety & pK of IV loading dose of lacosamide in the ICU about?
A restrospective review of patients treated in the ICU for refractory status epilepticus who had received an initial IV loading dose of lacosamide (LCS) was performed. A total of 142 patients were identified. The first 34 patients received 400mg which by weight-based measurement ranged from 2 to 11 mg/kg. Higher mg/kg dosing had been used subsequently with doses up to 13 mg/kg. No patient required reduction in rate or cessation of infusion. Initiation of pressor agents was not needed during the infusion of the loading dose. Postinfusion LCS blood levels were drawn, and dosing of 10-12 mg/kg and higher resulted in blood levels above 15 μg/ml while doses of 2-6 mg/kg resulted in levels below 10 μg/ml. We conclude that a weight-based loading dose of 10-12 mg/kg at an infusion rate of 0.4 mg/kg/min is safe and will produce levels of 15 μg/ml and higher. This article is part of a Special Issue entitled "Status Epilepticus".
Who reads Safety & pK of IV loading dose of lacosamide in the ICU?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- R. Eugene Ramsay; Vivek Sabharwal; Fawad Khan; Hina Dave; Cyrus Kafai; Rachel Shumate; Megan Irland
- Publisher
- Elsevier BV
- Published
- 2015
- Language
- EN
- Field
- Medicine (Health Sciences)