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Long-term body mass index changes in overweight and obese adults and the risk of heart failure, cardiovascular disease and mortality: a cohort study of over 260,000 adults in the UK by Iyen, Barbara (author);Weng, Stephen (author);Vinogradova, Yana (author);Akyea, Ralph K. (author);Qureshi, Nadeem (author);Kai, Joe (author) is a Medicine article available to read on EtoBox.
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## Background Although obesity is a well-recognised risk factor for cardiovascular disease (CVD), the impact of long-term body mass index (BMI) changes in overweight or obese adults, on the risk of heart failure, CVD and mortality has not been quantified. ## Methods This population-based cohort study used routine UK primary care electronic health data linked to secondary care and death-registry records. We identified adults who were overweight or obese, free from CVD and who had repeated BMI measures. Using group-based trajectory modelling, we examined the BMI trajectories of these individuals and then determined incidence rates of CVD, heart failure and mortality associated with the different trajectories. Cox-proportional hazards regression determined hazards ratios for incident outcomes. ## Results 264,230 individuals (mean age 49.5 years (SD 12.7) and mean BMI 33.8 kg/m^2^ (SD 6.1)) were followed-up for a median duration of 10.9 years. Four BMI trajectories were identified, corresponding at baseline, with World Health Organisation BMI classifications for overweight, class-1, class-2 and class-3 obesity respectively. In all four groups, there was a small, stable upwards trajecto
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- Author
- Iyen, Barbara (author);Weng, Stephen (author);Vinogradova, Yana (author);Akyea, Ralph K. (author);Qureshi, Nadeem (author);Kai, Joe (author)
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)