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Quantitative assessment of macromolecular concentration during direct infusion into an agarose hydrogel phantom using contrast-enhanced MRI by Xiaoming Chen; Garrett W. Astary; Hector Sepulveda; Thomas H. Mareci; Malisa Sarntinoranont is a Medicine article available to read on EtoBox.
What is Quantitative assessment of macromolecular concentration during direct infusion into an agarose hydrogel phantom using contrast-enhanced MRI about?
Convection-enhanced delivery (CED), that is, direct tissue infusion, has emerged as a promising local drug delivery method for treating diseases of the nervous system. Determination of the spatial distribution of therapeutic agents after infusion is important in evaluating the efficacy of treatment, optimizing infusion protocols and improving the understanding of drug pharmacokinetics. In this study, we provide a methodology to determine the concentration distribution of Gd-labeled tracers during infusion using contrast-enhanced magnetic resonance imaging (MRI). To the best of our knowledge, MR studies that quantify concentration profiles for CED have not been previously reported. The methodology utilizes intrinsic material properties (T(1) and R(1)) and reduces the effect of instrumental factors (e.g., inhomogeneity of MR detection field). As a methodology investigation, this study used an agarose hydrogel phantom as a tissue substitute for infusion. An 11.1-T magnet system was used to image infusion of Gd-DTPA-labeled albumin (Gd-albumin) into the hydrogel. By using data from preliminary scans, Gd-albumin distribution was determined from the signal intensity of the MR images. As
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- Author
- Xiaoming Chen; Garrett W. Astary; Hector Sepulveda; Thomas H. Mareci; Malisa Sarntinoranont
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0730-725X)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)