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Factor VII/VIIa: a new antigen in the anti-phospholipid antibody syndrome by Carlos J. Bidot; Wenche Jy; Lawrence L. Horstman; Huang Huisheng; Joaquin J. Jimenez; Miriam Yaniz; Yeon S. Ahn is a Medicine article available to read on EtoBox.

What is Factor VII/VIIa: a new antigen in the anti-phospholipid antibody syndrome about?

**Summary.** We investigated antibodies to factor VII/VIIa (FVII/VIIa) and five other common target antigens in 33 patients with a history of anti‐phospholipid syndrome (APS) and 50 healthy controls using an enzyme‐linked immunosorbent assay (ELISA) technique. We found that antibody to FVII/VIIa, a previously unrecognized and common antigen in APS, was present in 67% of patients. Frequencies of antibodies to other target antigens were: anti‐beta‐2 glycoprotein 1 (anti‐β2GP1), 88%; anti‐cardiolipin (anti‐CL), 76%; anti‐phosphatidylethanolamine (anti‐PE), 67%; anti‐phosphatidylserine (anti‐PS), 64%; and anti‐phosphatidylcholine (anti‐PC), 59%. Most patients had antibodies against multiple antigens, but a few were positive for only anti‐β2GP1 (12%) or anti‐CL (3%). Positivity for anti‐FVII/VIIa was significantly associated with positivity for anti‐PE, anti‐PS and/or anti‐PC (__P__ < 0·05) but not anti‐β2GP1. When frequencies of immunoglobulin G (IgG) versus immunoglobulin M (IgM) antibodies were compared, anti‐β2GP1 IgG correlated with the lupus anticoagulant (__P__ < 0·05) and was significantly more prevalent than IgM, but the reverse was seen for all other antigens. In arterial thro

Who reads Factor VII/VIIa: a new antigen in the anti-phospholipid antibody syndrome?

Author

Carlos J. Bidot; Wenche Jy; Lawrence L. Horstman; Huang Huisheng; Joaquin J. Jimenez; Miriam Yaniz; Yeon S. Ahn

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)

Published

2003

Language

EN

Field

Medicine (Health Sciences)