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Can I read Medroxyprogesterone Acetate Impairs Amyloid Beta Degradation in a Matrix Metalloproteinase-9 Dependent Manner on EtoBox?
Medroxyprogesterone Acetate Impairs Amyloid Beta Degradation in a Matrix Metalloproteinase-9 Dependent Manner by Porter, Keyana N.; Sarkar, Saumyendra N.; Dakhlallah, Duaa A.; Vannoy, Mya E.; Quintana, Dominic D.; Simpkins, James W. is a Medicine article available to read on EtoBox.
What is Medroxyprogesterone Acetate Impairs Amyloid Beta Degradation in a Matrix Metalloproteinase-9 Dependent Manner about?
Despite the extensive use of hormonal methods as either contraception or menopausal hormone therapy (HT), there is very little known about the potential effects of these compounds on the cellular processes of the brain. Medroxyprogesterone Acetate (MPA) is a progestogen used globally in the hormonal contraceptive, Depo Provera, by women in their reproductive prime and is a major compound found in HT formulations used by menopausal women. MPA promotes changes in the circulating levels of matrix metalloproteinases (MMPs), such as MMP-9, in the endometrium, yet limited literature studying the effects of MPA on neurons and astroglia cells has been conducted. Additionally, the dysregulation of MMPs has been implicated in the pathology of Alzheimer’s disease (AD), where inhibiting the secretion of MMP-9 from astroglia reduces the proteolytic degradation of amyloid-beta. Thus, we hypothesize that exposure to MPA disrupts proteolytic degradation of amyloid-beta through the downregulation of MMP-9 expression and subsequent secretion. To assess the effect of progestins on MMP-9 and amyloid-beta, __in vitro__, C6 rat glial cells were exposed to MPA for 48 h and then the enzymatic, secretory,
Who reads Medroxyprogesterone Acetate Impairs Amyloid Beta Degradation in a Matrix Metalloproteinase-9 Dependent Manner?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Porter, Keyana N.; Sarkar, Saumyendra N.; Dakhlallah, Duaa A.; Vannoy, Mya E.; Quintana, Dominic D.; Simpkins, James W.
- Publisher
- Frontiers; Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2009- (ISSN 1663-4365)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)