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Can I read Metabolic stabilization of benzylidene ketal M2 muscarinic receptor antagonists via halonaphthoic acid substitution on EtoBox?
Metabolic stabilization of benzylidene ketal M2 muscarinic receptor antagonists via halonaphthoic acid substitution by Craig D. Boyle; Samuel Chackalamannil; John W. Clader; William J. Greenlee; Hubert B. Josien; James J. Kaminski; Joseph A. Kozlowski; Stuart W. McCombie; Dennis V. Nazareno; Jayaram R. Tagat; Yuguang Wang; Guowei Zhou; William Billard; Herbert Binch III; Gordon Crosby; Mary Cohen-Williams; Vicki L. Coffin; Kathleen A. Cox; Diane E. Grotz; Ruth A. Duffy; Vilma Ruperto; Jean E. Lachowicz is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Metabolic stabilization of benzylidene ketal M2 muscarinic receptor antagonists via halonaphthoic acid substitution about?
The potential toxicological liabilities of the M 2 muscarinic antagonist 1 were addressed by replacing the methylenedioxyphenyl moiety with a p-methoxyphenyl group, resulting in M 2 selective compounds such as 3. Several halogenated naphthamide derivatives of 3 were studied in order to improve the pharmacokinetic profile via blockage of oxidative metabolism. Compound 4 demonstrated excellent M 2 affinity and selectivity, human microsomal stability, and oral bioavailability in rodents and primates.
Who reads Metabolic stabilization of benzylidene ketal M2 muscarinic receptor antagonists via halonaphthoic acid substitution?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Craig D. Boyle; Samuel Chackalamannil; John W. Clader; William J. Greenlee; Hubert B. Josien; James J. Kaminski; Joseph A. Kozlowski; Stuart W. McCombie; Dennis V. Nazareno; Jayaram R. Tagat; Yuguang Wang; Guowei Zhou; William Billard; Herbert Binch III; Gordon Crosby; Mary Cohen-Williams; Vicki L. Coffin; Kathleen A. Cox; Diane E. Grotz; Ruth A. Duffy; Vilma Ruperto; Jean E. Lachowicz
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2001
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)