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Can I read Bodyweight and Absolute Lymphocyte Count Based Dosing of Rabbit Anti-Thymocyte Globulin Results in Early CD4+ Immune Reconstitution in Patients with Inborn Errors of Metabolism Undergoing Umbilical Cord Blood Transplantation on EtoBox?
Bodyweight and Absolute Lymphocyte Count Based Dosing of Rabbit Anti-Thymocyte Globulin Results in Early CD4+ Immune Reconstitution in Patients with Inborn Errors of Metabolism Undergoing Umbilical Cord Blood Transplantation by Dr. Daniel Drozdov; Susie E. Long; Ashish O. Gupta; Dr. Troy C. Lund; Jaap Jan Boelens; Paul J. Orchard is a Medicine article available to read on EtoBox.
What is Bodyweight and Absolute Lymphocyte Count Based Dosing of Rabbit Anti-Thymocyte Globulin Results in Early CD4+ Immune Reconstitution in Patients with Inborn Errors of Metabolism Undergoing Umbilical Cord Blood Transplantation about?
26 patients (Figure 1). Overall survival was 83% (95% CI 67% to 100%), Figure 2. Median time to neutrophil engraftment was 14 days (IQR 12.5 to 18.0), and no graft failure was observed. All surviving patients had full myeloid and 14 of 23 (61%) of patients had full T-cell donor chimerism at one year post HCT. Two (7%) patients developed acute GVHD grade II to IV (Figure 3), and no patients had chronic GVHD. Six patients (22%) had cytomegalovirus viremia. One patient, who was seronegative before transplant, had Epstein-Barr virus reactivation requiring treatment, no patient had adenovirus reactivation. ## Conclusion: In patients with IEM individualized dosing of rATG was associated with a robust and early CD4+ immune reconstitution, with low therapy related mortality, low GVHD incidence compared to historical findings and stable full myeloid chimerism.
Who reads Bodyweight and Absolute Lymphocyte Count Based Dosing of Rabbit Anti-Thymocyte Globulin Results in Early CD4+ Immune Reconstitution in Patients with Inborn Errors of Metabolism Undergoing Umbilical Cord Blood Transplantation?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Dr. Daniel Drozdov; Susie E. Long; Ashish O. Gupta; Dr. Troy C. Lund; Jaap Jan Boelens; Paul J. Orchard
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)