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Dual-functional borosilicate glass (BSG) delivery implant for osteomyelitis treatment and bone regeneration by Hao Zhang; Li Li; Lei Chu; Jing Huang; Xiaochen Chen; Xianglong Zhuo; Yulin Wang; John Robert Honiball; Bin Wang; Wei Chen; William W. Lu; Deping Wang; Bing Li; Xu Cui; Haobo Pan is a Engineering article available to read on EtoBox.

What is Dual-functional borosilicate glass (BSG) delivery implant for osteomyelitis treatment and bone regeneration about?

Effective treatment of osteomyelitis remains to be clinical challenge due to the recurrent and persistent nature of the disease. Studies have shown that borate glasses can serve as implants for local drug delivery in treating osteomyelitis, as well as aid in regenerating bone defects in vivo. However, both the kinetics of drug release from borate glass-based implants and the underlying molecular mechanism for promoting bone regeneration remain unclear. Here, delivery implants with varying amounts of antibiotics were fabricated by encapsulating gentamicin sulfate (GS) into a chitosan glue and applying it to borosilicate glass (BSG). Upon immersion in phosphate buffered saline (PBS), delivery implants degraded and converted into hydroxyapatite (HA). All delivery implants released GS sustainably over a period of around 25 days in both PBS and K2HPO4 solutions and displayed efficacious inhibition of E. coli and S. aureus in vitro. GS release occurred through diffusion for inhibition whereby Fickian diffusion was revealed to be the predominant release kinetic. Ions (B, Ca, P and Si) released from BSG supported the proliferation, differentiation, osteogenic gene expression and protein se

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Author

Hao Zhang; Li Li; Lei Chu; Jing Huang; Xiaochen Chen; Xianglong Zhuo; Yulin Wang; John Robert Honiball; Bin Wang; Wei Chen; William W. Lu; Deping Wang; Bing Li; Xu Cui; Haobo Pan

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Engineering (Physical Sciences)