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An asymmetric synthesis of (+)paroxetine from the chiral non racemic lactam 1 is reported. The p-fluorophenyl substituent is introduced by conjugate addition to the unsaturated lactams 3. The alkoxycarbonyl group in 3 is the precursor of the hydroxymethyl group required for the subsequent assembly of the aryloxymethyl substiment at the piperidine 3-position.

Author

Calamidad Loco Peligro

Language

EN