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Synthesis and antimicrobial evaluation of some heterocyclic compounds from 3-aryl-1-phenyl-1 H -pyrazole-4-carbaldehydes by El Sayed Ramadan; Essam M. Sharshira; Ramadan I. El Sokkary; Noussa Morsy is a Chemistry article available to read on EtoBox.

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## Abstract A new series of chalcones, pyrazolinyl-pyrazoles, pyrazole-4-carbaldehyde oximes, pyrazole-4-carbonitriles, 5-pyrazolyl-1,2,4-triazolidine-3-thiones, and Knoevenagel condensation products was synthesized from 3-aryl-1-phenyl-1__H__-pyrazole-4-carbaldehydes. Most reactions were carried out either without solvent or in the presence of water as a green solvent. The structure of synthesized compounds was characterized by spectral and elemental analysis. The synthesized compounds were tested __in vitro__ for their antimicrobial activity against __Escherichia coli__, __Staphylococcus aureus__, and __Candida albicans__ in comparison with imipenem (intravenous __β__-lactam antibiotic) and clotrimazole (antifungal medication) as reference drugs by using the agar diffusion technique. 3-Aryl-1-phenyl-1__H__-pyrazole-4-carbonitriles 8b, 8c, and 8d showed significant antifungal activity against the fungus __C. albicans__.

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Author

El Sayed Ramadan; Essam M. Sharshira; Ramadan I. El Sokkary; Noussa Morsy

Publisher

Walter de Gruyter GmbH

Published

2018

Language

EN

Field

Chemistry (Physical Sciences)