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Anti-photobleaching cyanine-based nanoparticles with simultaneous PET and ACQ effects for improved tumor photothermal therapy by Feng, Erting (author);Jiao, Long (author);Tang, Shanliang (author);Chen, Miaomiao (author);Lv, Shibo (author);Liu, Dapeng (author);Song, Jitao (author);Zheng, Daoyuan (author);Peng, Xiaojun (author);Song, Fengling (author) is a Engineering article available to read on EtoBox.

What is Anti-photobleaching cyanine-based nanoparticles with simultaneous PET and ACQ effects for improved tumor photothermal therapy about?

To design anti-photobleaching photothermal agents (PTAs) is of great significance for tumor photothermal therapy (PTT). Heptamethine cyanine (Cy7) dyes as one of near-infrared (NIR) PTAs has received extensive attention in PTT. But the poor photostability of Cy7 dyes severely restrict their clinical application. Herein, two new Cy7 dyes DTZCy and WTZCy were prepared, which showed better anti-photobleaching performance than ICG, a commercial Cy7 dye proved by FDA. Noteworthily, the contributions of quenching fluorescence and enhancing photostability to improving the photothermal conversion efficiency (PCE) of Cy7-based PTAs were discussed. DTZCy exhibited much better PCE (η = 31.8%) than WTZCy (η = 16.5%) due to the increased photostability caused by the intramolecular photoinduced electron transfer (PET) effect. Silica nanoparticles encapsulating DTZCy, named as DTZCy@SiO 2 NPs, displayed higher PCE (η = 34.6%) and satisfying photothermal stability both in vitro and vivo, which was attributed to the improved anti-photobleached ability caused by aggregation-caused quenching (ACQ) mechanism. This work may provide new strategies for constructing antiphotobleaching PTAs by simultaneous

Who reads Anti-photobleaching cyanine-based nanoparticles with simultaneous PET and ACQ effects for improved tumor photothermal therapy?

It is typically read by researchers, students, and practitioners in Engineering.

Author
Feng, Erting (author);Jiao, Long (author);Tang, Shanliang (author);Chen, Miaomiao (author);Lv, Shibo (author);Liu, Dapeng (author);Song, Jitao (author);Zheng, Daoyuan (author);Peng, Xiaojun (author);Song, Fengling (author)
Publisher
Elsevier BV
Published
2022
Language
EN
Field
Engineering (Physical Sciences)

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