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The document reviews evidence for the role of brain CB2 receptors in neuropsychiatric disorders. It discusses how CB2 receptors are expressed in the central nervous system on microglia, astrocytes and neurons. Under inflammatory conditions, CB2 receptor expression is enhanced and CB2 receptor agonists exhibit anti-inflammatory effects, prompting research into CB2 as a target for neuroinflammatory and neurodegenerative disorders. Polymorphisms in the CB2 gene have also been reported in depression, eating dis

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