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Effect of pressure up to 5.5 GPa on dry powder samples of chlorpropamide form-A by Elena V. Boldyreva; Vladimir Dmitriev; Bruno C. Hancock is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

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The effect of pressure up to 5.5 GPa on a dry powder sample of chlorpropamide (4-chloro-N-((propylamino)-carbonyl)-benzenesulfonamide), form-A (sp. gr. P2 1 2 1 2 1 , a = 9.066 Å, b = 5.218 Å, c = 26.604 Å), was studied in situ in a Merrill-Bassett diamond anvil cell using high-resolution Xray powder diffraction (a synchrotron radiation source at SNBL ESRF, Grenoble). No evidence of the polymorphic transformation of chlorpropamide form-A to form-C was observed. The A-C polymorphic transition on tabletting previously reported by Otsuka et al. (1989) is therefore likely to be due to local heating effects. Similarly, the phase transitions of form-A reported by Cao (2002) to be induced by pressure applied to a sample in its saturated ethanol solution (at 0.9 and at 2.0 GPa) would appear to be solvent-mediated. In the dry sample, a phase transition may be supposed to occur at pressures above 4 GPa, but this requires further studies.

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Author

Elena V. Boldyreva; Vladimir Dmitriev; Bruno C. Hancock

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)

Published

2006

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)