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Can I read Bacterial Indole-3-lactic Acid Affects Epithelium–macrophage Crosstalk to Regulate Intestinal Homeostasis on EtoBox?
Bacterial Indole-3-lactic Acid Affects Epithelium–macrophage Crosstalk to Regulate Intestinal Homeostasis by Kaiyuan Yu; Qianqian Li; Xuan Sun; Xianping Peng; Qiang Tang; Hongyu Chu; Lu Zhou; Bangmao Wang; Zhemin Zhou; Xueqin Deng; Jianming Yang; Junqiang Lv; Ran Liu; Chunhui Miao; Wei Zhao; Zhi Yao; Quan Wang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Bacterial Indole-3-lactic Acid Affects Epithelium–macrophage Crosstalk to Regulate Intestinal Homeostasis about?
## Significance The microbiome is crucial to the maintenance of intestinal homeostasis. Here, we investigated that an isolated human fecal bacteria strain and its derived ILA regulated intestinal homeostasis. ILA reduces glycolysis, NF-κB, and HIF pathways to decrease CCL2/7 in epithelial cells, thereby decreasing the accumulation of inflammatory macrophages. These findings determine the role and mechanism of bacteria-derived ILA in regulating intestinal homeostasis and provide evidence that ILA has therapeutic potential for IBD.
Who reads Bacterial Indole-3-lactic Acid Affects Epithelium–macrophage Crosstalk to Regulate Intestinal Homeostasis?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Kaiyuan Yu; Qianqian Li; Xuan Sun; Xianping Peng; Qiang Tang; Hongyu Chu; Lu Zhou; Bangmao Wang; Zhemin Zhou; Xueqin Deng; Jianming Yang; Junqiang Lv; Ran Liu; Chunhui Miao; Wei Zhao; Zhi Yao; Quan Wang
- Publisher
- National Academy of Sciences
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)