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Genetic Alterations in Poorly Differentiated Endocrine Carcinomas of the Gastrointestinal Tract by Silvia Pizzi; Cinzia Azzoni; Daniela Bassi; Lorena Bottarelli; Massimo Milione; Cesare Bordi is a Medicine article available to read on EtoBox.
What is Genetic Alterations in Poorly Differentiated Endocrine Carcinomas of the Gastrointestinal Tract about?
## Abstract ## BACKGROUND The molecular pathogenesis of poorly differentiated endocrine carcinomas of the gastrointestinal tract (GI PDECs) remains unclear. It has been suggested that these lesions either originate from multipotent stem cells that also can serve as the origin of nonendocrine adenocarcinomas or arise due to the dedifferentiation of well‐differentiated endocrine carcinomas (WDECs). ## METHODS Ten gastric and 9 colorectal PDECs, 9 gastric WDECs, and 12 colorectal carcinomas (CRCs) were analyzed for loss of heterozygosity (LOH) at 11q13 (__MEN1__), 17p13.1 (__p53__), 3p14.2 (__FHIT__), 3p21.3 (__RASSF1A__), and 18q23 (__DCC/DPC4/Smad2__), and for immunohistochemical expression of p53, FHIT, Rb, and p16. ## RESULTS PDECs exhibited high fractional allelic loss (FAL; 0.49), with frequent (> 40%) alterations in __p53__, __Rb__, __MEN1__, __FHIT__, and 18q. No significant differences were found between gastric and colorectal PDECs. Gastric WDECs also exhibited high FAL (0.44), with frequent alterations in __Rb__ and/or __p16__, __MEN1__, and 3p21. CRCs exhibited a low level of FAL (0.23), with frequent (> 50%) __p16__ and __p53__ alterations. When gastric PDECs and WDECs we
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- Author
- Silvia Pizzi; Cinzia Azzoni; Daniela Bassi; Lorena Bottarelli; Massimo Milione; Cesare Bordi
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)