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T‐lymphocyte and glycemic status after vitamin D treatment in type 1 diabetes: A randomized controlled trial with sequential crossover by D. Bogdanou; M. Penna‐Martinez; N. Filmann; T.L. Chung; Y. Moran‐Auth; J. Wehrle; C. Cappel; S. Huenecke; E. Herrmann; U. Koehl; K. Badenhoop is a Medicine article available to read on EtoBox.

What is T‐lymphocyte and glycemic status after vitamin D treatment in type 1 diabetes: A randomized controlled trial with sequential crossover about?

## Abstract ## Background Type 1 diabetes mellitus (T1D) is mediated by autoaggressive T effector cells with an underlying regulatory T‐cell (Treg) defect. Vitamin D deficiency is highly prevalent in T1D, which can aggravate immune dysfunction. High‐dose vitamin D treatment may enhance Tregs and improve metabolism in T1D patients. ## Methods In a randomized double‐blind placebo‐controlled trial with crossover design, patients received either for 3 months cholecalciferol 4000 IU/d followed by 3 months placebo or the sequential alternative. Thirty‐nine T1D patients (19 women and 20 men) completed the trial. ## Results Primary outcome was a change of Tregs, secondary HbA1C, and insulin demand. Effects were evaluated based on intra‐individual changes between treatment and placebo periods for outcome measures. Exploratory analyses included vitamin D system variant genotyping and C‐peptide measurements. Median 25(OH)D~3~ increased to 38.8 ng/ml with males showing a significantly stronger increase (p = .003). T‐lymphocyte profiles did not change significantly (p > 2); however, the intra‐individual change of Tregs between males and females was different with a significantly stronger increa

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Author

D. Bogdanou; M. Penna‐Martinez; N. Filmann; T.L. Chung; Y. Moran‐Auth; J. Wehrle; C. Cappel; S. Huenecke; E. Herrmann; U. Koehl; K. Badenhoop

Publisher

Wiley

Published

2016

Language

EN

Field

Medicine (Health Sciences)