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An Evolutionary Relationship Between Genetic Variation and Phenotypic Fluctuation by Kunihiko Kaneko; Chikara Furusawa is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is An Evolutionary Relationship Between Genetic Variation and Phenotypic Fluctuation about?

The relevance of phenotype fluctuations among clones (i.e., organisms with identical genes) to evolution has recently been recognized both theoretically and experimentally. By considering the stability of the distributions of genetic variations and phenotype fluctuations, we derive a general inequality between the phenotype variance due to genetic differences and the intrinsic phenotype variance of clones. For a given mutation rate, an approximately linear relationship between the two is obtained which elucidates the consistency between the fundamental theorem of natural selection by Fisher and the evolutionary fluctuation-response relationship (fluctuation dissipation theorem) proposed recently. A general condition for the error catastrophe is also derived as the violation of the inequality, which sets up the limit to the speed of stable evolution. All of these theoretical results are confirmed by a numerical evolution experiment of a cell that consists of a catalytic reaction network. Based on the relationships proposed here, relevance of the phenotypic plasticity to evolution as well as the genetic assimilation is discussed.

Who reads An Evolutionary Relationship Between Genetic Variation and Phenotypic Fluctuation?

Author

Kunihiko Kaneko; Chikara Furusawa

Publisher

Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0022-5193)

Published

2006

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)