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Therapeutic drugs modulate ATP-Binding cassette transporter-mediated transport of amyloid beta(1–42) in brain microvascular endothelial cells by Shubbar, Maryam H.; Penny, Jeffrey I. is a Neuroscience article available to read on EtoBox.
What is Therapeutic drugs modulate ATP-Binding cassette transporter-mediated transport of amyloid beta(1–42) in brain microvascular endothelial cells about?
Deposition of amyloid-β peptide (Aβ (1-42) ) is a hallmark of Alzheimer's disease. Clearance of Aβ (1-42) , across the blood-brain barrier (BBB), is mediated by ATP-binding Cassette (ABC) efflux transporters. Many therapeutic drugs inhibit ABC transporters, but little is known of the effect of therapeutic drugs on Aβ (1-42) transport across BBB endothelial cells. The effects of selected, widely prescribed, therapeutic drugs on ABCB1, ABCC5 and ABCG2 activities were determined by measuring intracellular levels of calcein, GS-MF, and Hoechst 33342 respectively in primary porcine brain endothelial cells (PBECs). The ability of ABCB1, ABCC5 and ABCG2 to transport Aβ (1-42) was determined using fluorescent Aβ (1-42) . The ability of the ABCB1, ABCC5 and ABCG2 inhibitor telmisartan to modify transcellular Aβ (1-42) transport was investigated using PBEC monolayers housed in Transwell® inserts. Treatment of PBECs with ABC transporter inhibitory drugs (indomethacin, olanzapine, chlorpromazine, telmisartan, pantoprazole, quinidine, sulfasalazine and nefazodone) increased Aβ (1-42) intracellular accumulation. Inhibition of ABCB1, ABCC5 and ABCG2 by telmisartan increased Aβ (1-42) transport in
Who reads Therapeutic drugs modulate ATP-Binding cassette transporter-mediated transport of amyloid beta(1–42) in brain microvascular endothelial cells?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Shubbar, Maryam H.; Penny, Jeffrey I.
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0014-2999)
- Published
- 2020
- Language
- EN
- Field
- Neuroscience (Life Sciences)