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Endovascular Thrombectomy with or without Intravenous Alteplase in Acute Stroke by Pengfei Yang; Yongwei Zhang; Lei Zhang; Yongxin Zhang; Kilian M. Treurniet; Wenhuo Chen; Ya Peng; Hongxing Han; Jiyue Wang; Shouchun Wang; Congguo Yin; Sheng Liu; Peng Wang; Qi Fang; Hongchao Shi; Jianhong Yang; Changming Wen; Conghui Li; Changchun Jiang; Jun Sun; Xincan Yue; Min Lou; Meng Zhang; Hansheng Shu; Dianjing Sun; Hui Liang; Tong Li; Fuqiang Guo; Kaifu Ke; Haicheng Yuan; Guoping Wang; Weimin Yang; Huaizhang Shi; Tianxiao Li; Zifu Li; Pengfei Xing; Ping Zhang; Yu Zhou; Hao Wang; Yi Xu; Qinghai Huang; Tao Wu; Rui Zhao; Qiang Li; Yibin Fang; Laixing Wang; Jianping Lu; Yansheng Li; Jianhui Fu; Xihua Zhong; Yongjun Wang; Longde Wang; Mayank Goyal; Diederik W.J. Dippel; Bo Hong; Benqiang Deng; Yvo B.W.E.M. Roos; Charles B.L.M. Majoie; Jianmin Liu is a Medicine article available to read on EtoBox.
What is Endovascular Thrombectomy with or without Intravenous Alteplase in Acute Stroke about?
## Background: In acute ischemic stroke, there is uncertainty regarding the benefit and risk of administering intravenous alteplase before endovascular thrombectomy. ## Methods: We conducted a trial at 41 academic tertiary care centers in china to evaluate endovascular thrombectomy with or without intravenous alteplase in patients with acute ischemic stroke. patients with acute ischemic stroke from large-vessel occlusion in the anterior circulation were randomly assigned in a 1:1 ratio to undergo endovascular thrombectomy alone (thrombectomy-alone group) or endovascular thrombectomy preceded by intravenous alteplase, at a dose of 0.9 mg per kilogram of body weight, administered within 4.5 hours after symptom onset (combination-therapy group). the primary analysis for noninferiority assessed the between-group difference in the distribution of the modified rankin scale scores (range, 0 [no symptoms] to 6 [death]) at 90 days on the basis of a lower boundary of the 95% confidence interval of the adjusted common odds ratio equal to or larger than 0.8. we assessed various secondary outcomes, including death and reperfusion of the ischemic area. ## Results: Of 1586 patients screened, 656
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- Author
- Pengfei Yang; Yongwei Zhang; Lei Zhang; Yongxin Zhang; Kilian M. Treurniet; Wenhuo Chen; Ya Peng; Hongxing Han; Jiyue Wang; Shouchun Wang; Congguo Yin; Sheng Liu; Peng Wang; Qi Fang; Hongchao Shi; Jianhong Yang; Changming Wen; Conghui Li; Changchun Jiang; Jun Sun; Xincan Yue; Min Lou; Meng Zhang; Hansheng Shu; Dianjing Sun; Hui Liang; Tong Li; Fuqiang Guo; Kaifu Ke; Haicheng Yuan; Guoping Wang; Weimin Yang; Huaizhang Shi; Tianxiao Li; Zifu Li; Pengfei Xing; Ping Zhang; Yu Zhou; Hao Wang; Yi Xu; Qinghai Huang; Tao Wu; Rui Zhao; Qiang Li; Yibin Fang; Laixing Wang; Jianping Lu; Yansheng Li; Jianhui Fu; Xihua Zhong; Yongjun Wang; Longde Wang; Mayank Goyal; Diederik W.J. Dippel; Bo Hong; Benqiang Deng; Yvo B.W.E.M. Roos; Charles B.L.M. Majoie; Jianmin Liu
- Publisher
- Massachusetts Medical Society
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)