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What is HLA Allele Frequency Meta-Analysis about?

This paper presents a meta-analysis of human leukocyte antigen (HLA) allele frequency data from 497 population samples representing approximately 66,800 individuals worldwide. The analysis aimed to observe trends in balancing selection across HLA loci that may not have been evident previously. Measures of allele frequency distributions were summarized by locus and region. Results confirmed a role for balancing selection in maintaining HLA variation, and ranked loci by strength of balancing selection, with D

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