Can I read Neurobehavioral Toxicity of Total Body Irradiation: a Follow-up in Long-term Survivors on EtoBox?

Neurobehavioral Toxicity of Total Body Irradiation: a Follow-up in Long-term Survivors by Martin Peper; Sarah Steinvorth; Peter Schraube; Stefan Fruehauf; Rainer Haas; Bernhard N Kimmig; Frank Lohr; Frederik Wenz; Michael Wannenmacher is a Medicine article available to read on EtoBox.

What is Neurobehavioral Toxicity of Total Body Irradiation: a Follow-up in Long-term Survivors about?

Purpose: Total body irradiation (TBI) in preparation for bone marrow transplantation (BMT) is a routine treatment of hematological malignancy. A retrospective and a prospective group study of long-term cerebral side effects was performed, with a special emphasis on neurobehavioral toxicity effects. Methods and Materials: Twenty disease-free patients treated with hyperfractionated TBI (14.4 Gy, 12 ؋ 1.2 Gy, 4 days), 50 mg/kg cyclophosphamide, and autologous BMT (mean age 38 years, range 17-52 years; age at TBI 35 years, 16 -50 years; follow-up time 32 months, 9 -65 months) participated in a neuropsychological, neuroradiological, and neurological examination. Data were compared to 14 patients who were investigated prior to TBI. Eleven patients with renal insufficiencies matched for sex and age (38 years, 20 -52 years) served as controls. In a longitudinal approach, neuropsychological follow-up data were assessed in 12 long-term survivors (45 years, 23-59 years; follow-up time 8.8 years, 7-10.8 years; time since diagnosis 10.1 years, 7.5-14.2 years). Results: No evidence of neurological deficits was found in post-TBI patients except one case of peripheral movement disorder of unknown

Who reads Neurobehavioral Toxicity of Total Body Irradiation: a Follow-up in Long-term Survivors?

Author

Martin Peper; Sarah Steinvorth; Peter Schraube; Stefan Fruehauf; Rainer Haas; Bernhard N Kimmig; Frank Lohr; Frederik Wenz; Michael Wannenmacher

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2000

Language

EN

Field

Medicine (Health Sciences)