Can I read Hydrolysis and Transesterification Reactions of Candesartan Cilexetil Observed During the Solid Phase Extraction Procedure on EtoBox?

Hydrolysis and Transesterification Reactions of Candesartan Cilexetil Observed During the Solid Phase Extraction Procedure by Nerea Ferreirós; Sebastian Dresen; Rosa María Alonso; Wolfgang Weinmann is a Chemistry article available to read on EtoBox.

What is Hydrolysis and Transesterification Reactions of Candesartan Cilexetil Observed During the Solid Phase Extraction Procedure about?

Candesartan cilexetil is an angiotensin receptor antagonist widely used in the treatment of high blood pressure. This prodrug is metabolised into candesartan, which blocks the receptors AT1 for angiotensin II decreasing the blood pressure levels. During the development of a solid phase extraction procedure for the chromatographic determination of eight antihypertensive compounds, lack of linearity and reproducibility was observed only for candesartan cilexetil. Due to this fact, a stability study for this prodrug was performed. It showed that the lack of linearity and reproducibility was based on hydrolysis and transesterification processes which occurred during the drying step after elution with methanol into glass tubes. These phenomena could be reproduced artificially under basic conditions, which demonstrated the presence of basic residues in glass tubes. The study of this potential hydrolysis and transesterification reactions is very important to assure that labile drugs containing ester groups remain unaffected.

Who reads Hydrolysis and Transesterification Reactions of Candesartan Cilexetil Observed During the Solid Phase Extraction Procedure?

Author

Nerea Ferreirós; Sebastian Dresen; Rosa María Alonso; Wolfgang Weinmann

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-376X)

Published

2007

Language

EN

Field

Chemistry (Physical Sciences)