Can I read Effect of Magnesium Sulfate and Nifedipine on the Risk of Developing Pulmonary Edema in Preterm Births on EtoBox?

Effect of Magnesium Sulfate and Nifedipine on the Risk of Developing Pulmonary Edema in Preterm Births by ChengWei Xiao; Mihnea Gangal; Haim A. Abenhaim is a Medicine article available to read on EtoBox.

What is Effect of Magnesium Sulfate and Nifedipine on the Risk of Developing Pulmonary Edema in Preterm Births about?

## Abstract Objective: To evaluate the risk of developing pulmonary edema in women exposed to nifedipine, magnesium sulfate (MgSO~4~), or both in a preterm setting. Study design: We carried out a retrospective case-control study at a large tertiary care center from 2007 to 2012. Cases of pulmonary edema were age, and gestational age matched to controls at a ratio of 1 case to 4 controls. Logistic regression analysis was used to estimate the effect of nifedipine and/or MgSO~4~ on the development of pulmonary edema while controlling for predetermined confounding variables. Stepwise logistic regression analysis was used to evaluate additional risk factors of pulmonary edema. Results: A total of 150 charts were reviewed (28 cases and 122 controls). Nifedipine did not increase the odds of developing pulmonary edema [adjusted odds ratio (OR)=1.22 (confidence interval (CI) 0.50, 3.01), P=0.67], whereas exposure to MgSO~4~, or both MgSO~4~ and nifedipine, significantly increased the risk of developing pulmonary edema [adjusted OR=3.91 (CI 1.44, 10.65), P=0.008 and adjusted OR=4.75 (CI 1.15, 19.71), P=0.032, respectively]. In the stratified analysis, this association persisted even in nonpr

Who reads Effect of Magnesium Sulfate and Nifedipine on the Risk of Developing Pulmonary Edema in Preterm Births?

Author

ChengWei Xiao; Mihnea Gangal; Haim A. Abenhaim

Publisher

Walter de Gruyter GmbH

Published

2014

Language

EN

Field

Medicine (Health Sciences)