Can I read Methodology for Characterization of Platinum-based Drug's Targeted Delivery Nanosystems on EtoBox?

Methodology for Characterization of Platinum-based Drug's Targeted Delivery Nanosystems by J. Zajda; A. Wróblewska; L. Ruzik; M. Matczuk is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Methodology for Characterization of Platinum-based Drug's Targeted Delivery Nanosystems about?

Conventional anticancer therapies exploiting platinum-based drugs rely principally on the intravascular injection of the therapeutic agent. The anticancer drug is distributed throughout the body by the systemic blood circulation undergoing cellular uptake, rapid clearance and excretion. Consequently, only a small portion of the platinum-based drug reaches the tumor site, which is associated with severe side effects. For this reason, targeted delivery systems are of great need since they offer enhanced and selective delivery of a drug to cancerous cells making the therapy safe and more effective. Up to date, a variety of the Pt-based drug targeted delivery systems (Pt-based DTDSs) utilizing nanomaterials have been developed and tested using a range of analytical techniques that provided essential information on their synthesis, stability, biodistribution and cytotoxicity. Here we summarize those experimental techniques indicating their applicability at different stages of the research, as well as pointing out their strengths, advantages, drawbacks and limitations. Also, the existing strategies and approaches are critically reviewed with the objective to reveal and give rise to the d

Who reads Methodology for Characterization of Platinum-based Drug's Targeted Delivery Nanosystems?

Author

J. Zajda; A. Wróblewska; L. Ruzik; M. Matczuk

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)