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Analysis of the effect of brexpiprazole on sleep architecture in patients with schizophrenia: A preliminary study by Yusuke Arai; Daimei Sasayama; Kazuaki Kuraishi; Shiho Murata; Nobuteru Usuda; Mika Tsuchida; Yuka Nakajima; Shinsuke Washizuka is a Medicine article available to read on EtoBox.
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## Abstract ## Background Brexpiprazole is an atypical antipsychotic drug widely used in Japan for the treatment of schizophrenia. Previous studies have investigated the therapeutic effects of some antipsychotics on sleep variables; however, to our knowledge, the effects of brexpiprazole on sleep architecture have not been examined in patients with schizophrenia. Therefore, we aimed to exploratorily investigate the effect of brexpiprazole on sleep variables measured by polysomnography in patients with schizophrenia. ## Methods This study included 10 patients with schizophrenia who were originally treated with haloperidol alone. Sleep variables of the participants were measured using polysomnography. After excluding those who did not meet the study criteria, seven patients (five men and two women; mean age [SD], 59.0 [10.0] years) were eligible for further analysis. Polysomnography was repeated at 4 weeks after the participants were prescribed brexpiprazole in addition to haloperidol. We compared the sleep architecture of the participants, measured using polysomnography, before and after taking brexpiprazole. ## Results Add‐on brexpiprazole significantly prolonged rapid eye movement
Who reads Analysis of the effect of brexpiprazole on sleep architecture in patients with schizophrenia: A preliminary study?
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- Author
- Yusuke Arai; Daimei Sasayama; Kazuaki Kuraishi; Shiho Murata; Nobuteru Usuda; Mika Tsuchida; Yuka Nakajima; Shinsuke Washizuka
- Publisher
- John Wiley and Sons Inc.
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)