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Genes predisposing to autoimmunity augment constitutive major histocompatibility complex class II-associated presentation of the self-antigen IgG2abin vivo by K. Bartnes; X. Li; M. Iwamoto; S. Izui; K. Hannestad is a Immunology and Microbiology article available to read on EtoBox.

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## Summary The self‐antigen IgG2a^b^ is poorly presented to a γ2a^b^ 435–451‐reactive I‐A^d^‐restricted T‐cell hybridoma unless available in high concentrations or targeted to Fcγ‐ or complement receptors. Environmental factors, probably the extent of microbial challenge, profoundly influence the constitutive γ2a^b^/I‐A^d^ presentation in IgC~H~^b^, H‐2^d^ mice. Here we report also a strong genetic impact. Constitutive presentation was highly efficient in spleen and thymus of (NZB × BXSB)F~1~ mice, which inherit a predisposition to develop lupus. Presentation correlated with disease progression and the serum levels of IgG2a^b^ and IgG2a^b^ complement factor 3 complexes. The finding that constitutive presentation was by far most efficient in males indicated that it was augmented by the Y chromosome‐linked autoimmune acceleration __Yaa__ gene. In line with previous data for healthy mice, constitutive γ2a^b^/I‐A^d^ presentation was most pronounced in the adherent spleen cell fraction and improved by further enrichment for dendritic cells. Notably, however, whereas in normal mice the γ2a^b^ determinant was undetectable on B cells lacking surface IgG2a^b^, such B cells contributed consi

Who reads Genes predisposing to autoimmunity augment constitutive major histocompatibility complex class II-associated presentation of the self-antigen IgG2abin vivo?

Author

K. Bartnes; X. Li; M. Iwamoto; S. Izui; K. Hannestad

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0019-2805)

Published

2000

Language

EN

Field

Immunology and Microbiology (Life Sciences)