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A CT-based radiomics nomogram for differentiation of focal nodular hyperplasia from hepatocellular carcinoma in the non-cirrhotic liver by Nie, Pei; Yang, Guangjie; Guo, Jian; Chen, Jingjing; Li, Xiaoli; Ji, Qinglian; Wu, Jie; Cui, Jingjing; Xu, Wenjian is a Medicine article available to read on EtoBox.
What is A CT-based radiomics nomogram for differentiation of focal nodular hyperplasia from hepatocellular carcinoma in the non-cirrhotic liver about?
## Background The purpose of this study was to develop and validate a radiomics nomogram for preoperative differentiating focal nodular hyperplasia (FNH) from hepatocellular carcinoma (HCC) in the non-cirrhotic liver. ## Methods A total of 156 patients with FNH (__n__ = 55) and HCC (__n__ = 101) were divided into a training set (__n__ = 119) and a validation set (__n__ = 37). Radiomics features were extracted from triphasic contrast CT images. A radiomics signature was constructed with the least absolute shrinkage and selection operator algorithm, and a radiomics score (Rad-score) was calculated. Clinical data and CT findings were assessed to build a clinical factors model. Combined with the Rad-score and independent clinical factors, a radiomics nomogram was constructed by multivariate logistic regression analysis. Nomogram performance was assessed with respect to discrimination and clinical usefulness. ## Results Four thousand two hundred twenty-seven features were extracted and reduced to 10 features as the most important discriminators to build the radiomics signature. The radiomics signature showed good discrimination in the training set (AUC [area under the curve], 0.964; 95%
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- Author
- Nie, Pei; Yang, Guangjie; Guo, Jian; Chen, Jingjing; Li, Xiaoli; Ji, Qinglian; Wu, Jie; Cui, Jingjing; Xu, Wenjian
- Publisher
- E-Med; Springer (Biomed Central Ltd.); BioMed Central; London: e-MED, 2000-; London: BioMed Central Ltd; E-MED LTD; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1470-7330)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)