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Anti-inflammatory alkaloids from lotus (Nelumbo nucifera Gaertn.) leaves by Hong-Yu Lin; Cheng-Pei Chung; Shih-Min Hsia; Yu-Chia Chang; Wenchang Chiang; Yueh-Hsiung Kuo; Yun-Lian Lin is a Agricultural and Biological Sciences article available to read on EtoBox.

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Lotus (Nelumbo nucifera Gaertn.) is an aquatic perennial; and lotus leaves were used for food and functional herbal tea in Asia, while alkaloids are regarded as important components. Total alkaloids (TAs), phenolic alkaloids (PAs), and non-PAs from lotus leaves revealed inhibitory effects on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals scavenging effects and nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. Five alkaloids were isolated and identified as asimilobine (1), roemerine (2), lysicamine (3), nuciferine (4), and N-methylcoclaurine (5). Of them, compounds 1 and 2 exhibited potency as direct NO scavengers while 5 exerted the highest DPPH radical-scavenging effect. Compound 5 also inhibited NO production with an IC 50 value of 6 μM through suppressing inducible NO synthase (iNOS) expression in LPS-induced RAW 264.7 macrophages. Compounds 2 and 3 inhibited NO production (IC 50 values of 21 and 25 μM, respectively) as well as iNOS and cyclooxygenase (COX)-2 expressions. Further, compound 5 occupied 27.5% of TAs by high-performance liquid chromatography (HPLC) analysis, which was mainly responsible for the activities. Besides, no obvious cyt

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Author

Hong-Yu Lin; Cheng-Pei Chung; Shih-Min Hsia; Yu-Chia Chang; Wenchang Chiang; Yueh-Hsiung Kuo; Yun-Lian Lin

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)