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Dynamic Play between Human N-α-acetyltransferase D and H4-mutant Histones: Molecular Dynamics Study by Shravan B. Rathod; Kinshuk Raj Srivastava is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Dynamic Play between Human N-α-acetyltransferase D and H4-mutant Histones: Molecular Dynamics Study about?

Background: Many N-terminal acetyltransferases (NATs) play important role in the posttranslational modifications of histone tails. Research showed that these enzymes have been reported upregulated in many cancers. NatD is known to acetylate H4/H2A at the N-terminal. During lung cancer, this enzyme competes with the protein kinase CK2α and blocks the phosphorylation of H4 and, acetylates. It also, we observed that H4 has various mutations at the N-terminal and we considered only four mutations (S1C, R3C, G4D and G4S) to study the impacts of these mutations on H4 binding with NatD using MD simulation. Objective: Our main objective in this study was to understand the structure and dynamics of hNatD under the influence of WT and MT H4 histones bindings. The previous experimental study reported that mutations on H4 N-terminus reduce the catalytic efficiency of N-Terminal acetylation. But here, we performed a molecular- level study thus, we can understand how these mutations (S1C, R3C, G4D and G4S) cause significant depletion in catalytic efficiency of hNatD. Methods: Purely computational approaches were employed to investigate the impacts of four mutations in human histone H4 on its bin

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Author

Shravan B. Rathod; Kinshuk Raj Srivastava

Publisher

Bentham Science Publishers Ltd.

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)