Can I read Regulation of Axonal Caliber, Neurofilament Content, and Nuclear Localization in Mature Sensory Neurons by Nerve Growth Factor on EtoBox?

Regulation of Axonal Caliber, Neurofilament Content, and Nuclear Localization in Mature Sensory Neurons by Nerve Growth Factor by Gold, BG; Mobley, WC; Matheson, SF is a Neuroscience article available to read on EtoBox.

What is Regulation of Axonal Caliber, Neurofilament Content, and Nuclear Localization in Mature Sensory Neurons by Nerve Growth Factor about?

The neuronal perikaryal response to axonal injury (axon reaction) includes reduction in axonal caliber beginning in the proximal portion of the nerve (somatofugal axonal atrophy), development of nuclear eccentricity, and chromatolysis. The means by which these events are triggered is unknown, but it has been argued that loss of a neurotrophic signal from the target of injured neurons plays a role. To date, the identity of this substance(s) remains unknown. In the present study, we have asked whether NGF normally functions to control axonal caliber of sensory neurons in the L4 and L5 dorsal root ganglia (DRG) of the adult rat. Two approaches were used: (1) NGF was continuously delivered to the proximal stump of a transected sciatic nerve to determine whether NGF administration would prevent the production of somatofugal axonal atrophy; and (2) NGF antisera were administered to normal animals to determine whether NGF deprivation would produce somatofugal axonal atrophy. In the first experiment, 9-week-old rats underwent a unilateral sciatic nerve transection at midthigh, and the proximal stump was connected to an osmotic pump containing either NGF or cytochrome C (as control). At 11

Who reads Regulation of Axonal Caliber, Neurofilament Content, and Nuclear Localization in Mature Sensory Neurons by Nerve Growth Factor?

Author

Gold, BG; Mobley, WC; Matheson, SF

Publisher

Society for Neuroscience (ISSN 0270-6474)

Published

1991

Language

EN

Field

Neuroscience (Life Sciences)