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Radiotherapy and Continuous Infusion 5-Fluorouracil in Patients with Nonresectable Pancreatic Carcinoma by Giovanni Boz; Antonino De Paoli; Roberto Innocente; Carlo Rossi; Giancarlo Tosolini; Paolo Pederzoli; Renato Talamini; Mauro G Trovò is a Medicine article available to read on EtoBox.

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The current standard local treatment for nonresectable pancreatic carcinoma is radiotherapy (RT) with concurrent 5-fluorouracil (5-FU); however, the optimal schedule for 5-FU administration has not been fully established. In this study, we report on our experience with the combination of RT and continuous infusion 5-FU in a group of patients with locally nonresectable pancreatic carcinoma. Methods and Materials: Forty-two patients with adenocarcinoma of the pancreas were enrolled in a prospective clinical trial. RT was delivered using a four-field technique to a total dose of 59.4 Gy in 33 fractions. 5-FU was given through a central venous catheter at a dose of 300 mg/m 2 /day, 7 d/wk, throughout the entire course of RT. Results: All patients completed the RT as planned, and 33 (78%) completed the full regimen of chemotherapy. Ten patients (23%) had a partial response, and 32 (77%) had stable disease. Subjective response, defined as the disappearance of symptoms observed at diagnosis, was also evaluated. Two patients (6%) had a complete, and 24 (75%) a partial, remission of symptoms. The median time to progression was 6.2 months, and the median survival time was 9.1 months. Conclus

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Author

Giovanni Boz; Antonino De Paoli; Roberto Innocente; Carlo Rossi; Giancarlo Tosolini; Paolo Pederzoli; Renato Talamini; Mauro G Trovò

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2001

Language

EN

Field

Medicine (Health Sciences)