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Can I read Risk factors for infection in chronic hepatitis C: A high prevalence of sexual exposure among human immunodeficiency virus-coinfected women on EtoBox?
Risk factors for infection in chronic hepatitis C: A high prevalence of sexual exposure among human immunodeficiency virus-coinfected women by Eduardo Fassio; Graciela Landeira; Cristina Longo; Nora Domínguez; Estela Alvarez; Gisela Gualano is a Medicine article available to read on EtoBox.
What is Risk factors for infection in chronic hepatitis C: A high prevalence of sexual exposure among human immunodeficiency virus-coinfected women about?
We read the article by Horiguchi et al. 1 with great interest. It is a commonly accepted dogma that inflammation induces necrosis and apoptosis of hepatocytes during liver damage. However, clinicians have found that inflammation does not always correlate with hepatocellular damage in chronic liver disease. How to explain the conflict? By using a well-established model of mice with specific deletion of signal transducer and activator of transcription 3 in myeloid cells (STAT3 myeÀ/À ), Horiguchi and colleagues surprisingly found more inflammatory cells, eg, neutrophils, but less necrosis/apoptosis in the liver of STAT3 myeÀ/À mice than in wild-type mice after carbon tetrachloride (CCl 4 ) treatment. STAT3 myeÀ/À mice had higher hepatic STAT3 activation and became resistant to hepatic oxidative stress after CCl 4 injection compared with wild-type mice. In contrast to STAT3 myeÀ/À mice, hepatocyte-specific STAT3 knockout (STAT3 HepÀ/À ) mice had more liver necrosis/apoptosis but less inflammation after CCl 4 treatment compared with wild-type mice. An additional deletion of hepatocyte STAT3 in STAT3 myeÀ/À mice restored CCl 4 -induced hepatic necrosis but reduced liver inflammation. Th
Who reads Risk factors for infection in chronic hepatitis C: A high prevalence of sexual exposure among human immunodeficiency virus-coinfected women?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Eduardo Fassio; Graciela Landeira; Cristina Longo; Nora Domínguez; Estela Alvarez; Gisela Gualano
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2011
- Language
- EN
- Field
- Medicine (Health Sciences)