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Can I read Causes of Death in Patients with Multiple Sclerosis and Matched Referent Subjects: a Population‐based Cohort Study on EtoBox?

Causes of Death in Patients with Multiple Sclerosis and Matched Referent Subjects: a Population‐based Cohort Study by A. Lalmohamed; M. T. Bazelier; T. P. Van Staa; B. M. J. Uitdehaag; H. G. M. Leufkens; A. De Boer; F. De Vries is a Medicine article available to read on EtoBox.

What is Causes of Death in Patients with Multiple Sclerosis and Matched Referent Subjects: a Population‐based Cohort Study about?

**Background and purpose:** Multiple sclerosis (MS) has been associated with increased mortality rates. However, influence of lifestyle parameters remains unknown, and inconsistencies exist regarding findings for causes of death. **Methods:** We conducted a population‐based cohort study using the General Practice Research Database, Hospital Episode Statistics, and national death certificates (January 2001 through March 2008). To each patient with MS (__n__ = 1270), up to six referent subjects without MS were matched by age, gender, and practice. Cox proportional hazards models were used to estimate mortality rate ratios (HRs). **Results:** Patients with MS had a 3.5‐fold increased mortality rate for all‐cause mortality, compared with referent subjects (HR 3.51, 95% CI 2.63–4.69). The rate further increased amongst current smokers (HR 6.72, 95% CI 4.16–10.87) (but not in ex‐smokers) and subjects with a body mass index of <20 kg/m^2^ (HR 6.67, 95% CI 3.50–12.73). The HR was highest for infectious/respiratory‐related deaths (HR 7.69, 95% CI 4.92–12.02) and was significantly increased for deaths related to cardiovascular diseases (2.4‐fold) and cancer (1.9‐fold), but not for accidents

Who reads Causes of Death in Patients with Multiple Sclerosis and Matched Referent Subjects: a Population‐based Cohort Study?

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Author
A. Lalmohamed; M. T. Bazelier; T. P. Van Staa; B. M. J. Uitdehaag; H. G. M. Leufkens; A. De Boer; F. De Vries
Publisher
Wiley
Published
2012
Language
EN
Field
Medicine (Health Sciences)

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