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Evaluation of Metabolic Control Using a Continuous Subcutaneous Glucose Monitoring System in Patients with Type 1 Diabetes Mellitus who Achieved Insulin Independence after Islet Cell Transplantation by Milene C. Geiger; Jacqueline V. Ferreira; Muhammad M. Hafiz; Tatiana Froud; David A. Baidal; Luigi F. Meneghini; Camillo Ricordi; Rodolfo Alejandro is a Medicine article available to read on EtoBox.

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This study evaluated the Medtronic MiniMed Continuous Glucose Monitoring System (CGMS) in patients with type 1 diabetes mellitus who underwent successful islet cell transplantation (ICT). The results are compared to standardized self-monitoring (SMBG) of hyperglycemia and mean amplitude of glycemic excursions (MAGE). We studied 19 patients (mean age 40.0 ± 6.7 years) in three groups: six patients post-ICT, seven patients awaiting ICT, and six normal volunteers (controls). Continuous glucose monitoring post-ICT showed remarkable glucose stability compared with patients awaiting ICT. The CGMS group showed modestly higher glucoses (mean 111.5 mg/dl) compared with controls (88 mg/dl). Postprandial glucoses in ICT recipients rarely exceeded 180 mg/dl and were similar to controls. There was no difference in asymptomatic hypoglycemia between control and post-ICT groups. However, a higher incidence of hypoglycemia was observed in patients awaiting ICT. HbA1c and MAGE pre- and post-ICT were 8.3 ± 0.9% and 6 ± 0.3% (p < 0.001) and 109 ± 34 and 41 ± 11 (p < 0.001), respectively. No complications were associated with CGMS. This study suggests ICT significantly improves metabolic control and ra

Who reads Evaluation of Metabolic Control Using a Continuous Subcutaneous Glucose Monitoring System in Patients with Type 1 Diabetes Mellitus who Achieved Insulin Independence after Islet Cell Transplantation?

Author

Milene C. Geiger; Jacqueline V. Ferreira; Muhammad M. Hafiz; Tatiana Froud; David A. Baidal; Luigi F. Meneghini; Camillo Ricordi; Rodolfo Alejandro

Publisher

Cognizant Communication Corporation; SAGE Publications; SAGE Publications Inc.; Elsevier BV (ISSN 0963-6897)

Published

2005

Language

EN

Field

Medicine (Health Sciences)