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What is GS-9620 TLR7 Agonist for Chronic HBV about?
This document summarizes two clinical trials evaluating the safety, pharmacokinetics, and pharmacodynamics of the oral TLR7 agonist GS-9620 in patients with chronic hepatitis B virus infection. In the trials, 49 treatment-naïve patients and 51 virologically suppressed patients were randomized to receive GS-9620 at doses of 0.3 mg, 1 mg, 2 mg, or 4 mg or placebo as a single dose or two doses 7 days apart. GS-9620 was generally well tolerated, with the most common adverse event being headache. GS-9620 induced
- Author
- ledaivanova
- Language
- EN