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Development and Validation of a Multivariable Model for Prediction of Malignant Transformation and Recurrence of Oral Epithelial Dysplasia by Hanya Mahmood; Adam Shephard; Paul Hankinson; Mike Bradburn; Anna Luiza Damaceno Araujo; Alan Roger Santos-Silva; Marcio Ajudarte Lopes; Pablo Agustin Vargas; Kris D. McCombe; Stephanie G. Craig; Jacqueline James; Jill Brooks; Paul Nankivell; Hisham Mehanna; Nasir Rajpoot; Syed Ali Khurram is a Medicine article available to read on EtoBox.

What is Development and Validation of a Multivariable Model for Prediction of Malignant Transformation and Recurrence of Oral Epithelial Dysplasia about?

## Background Oral epithelial dysplasia (OED) is the precursor to oral squamous cell carcinoma which is amongst the top ten cancers worldwide. Prognostic significance of conventional histological features in OED is not well established. Many additional histological abnormalities are seen in OED, but are insufficiently investigated, and have not been correlated to clinical outcomes. ## Methods A digital quantitative analysis of epithelial cellularity, nuclear geometry, cytoplasm staining intensity and epithelial architecture/thickness is conducted on 75 OED whole-slide images (252 regions of interest) with feature-specific comparisons between grades and against non-dysplastic/control cases. Multivariable models were developed to evaluate prediction of OED recurrence and malignant transformation. The best performing models were externally validated on unseen cases pooled from four different centres (__n__ = 121), of which 32% progressed to cancer, with an average transformation time of 45 months. ## Results Grade-based differences were seen for cytoplasmic eosin, nuclear eccentricity, and circularity in basal epithelial cells of OED (__p__ < 0.05). Nucleus circularity was associated

Who reads Development and Validation of a Multivariable Model for Prediction of Malignant Transformation and Recurrence of Oral Epithelial Dysplasia?

Author

Hanya Mahmood; Adam Shephard; Paul Hankinson; Mike Bradburn; Anna Luiza Damaceno Araujo; Alan Roger Santos-Silva; Marcio Ajudarte Lopes; Pablo Agustin Vargas; Kris D. McCombe; Stephanie G. Craig; Jacqueline James; Jill Brooks; Paul Nankivell; Hisham Mehanna; Nasir Rajpoot; Syed Ali Khurram

Publisher

Springer Science and Business Media LLC

Published

2023

Field

Medicine (Health Sciences)