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Frequency of Gastrointestinal Involvement and Its Clinical Significance in Mantle Cell Lymphoma by Jorge E. Romaguera; L. Jeffrey Medeiros; Frederick B. Hagemeister; Luis E. Fayad; Maria A. Rodriguez; Barbara Pro; Anas Younes; Peter McLaughlin; Andre Goy; Andreas H. Sarris; Nan H. Dang; Felipe Samaniego; H. M. Brown; Harish K. Gagneja; Fernando Cabanillas is a Medicine article available to read on EtoBox.

What is Frequency of Gastrointestinal Involvement and Its Clinical Significance in Mantle Cell Lymphoma about?

## Abstract ## BACKGROUND The reported frequency of gastrointestinal (GI) tract involvement in patients with mantle cell lymphoma (MCL) is 15–30%. However, this figure most likely is an underestimate because most patients with MCL involving the GI tract previously reported were examined endoscopically only if they had GI tract symptoms. The impact of endoscopic assessment on the management of MCL patients is unknown. ## METHODS From March 1998 to May 2001 baseline upper and lower endoscopy of the GI tract was performed in consecutive untreated patients with MCL as part of a prospective therapeutic trial. Biopsies were performed on abnormal as well as macroscopically normal mucosa. Endoscopy was repeated during treatment and as part of follow‐up evaluations. ## RESULTS Only 26% of patients presented with GI symptoms at the time of diagnosis. MCL was present histologically in the lower GI tract of 53 of 60 patient (88%) and in the upper GI tract of 28 of 58 patients (43%). Microscopic evidence of MCL was found in 84% of patients with normal visual (macroscopic) findings by lower endoscopy and in 45% of patients with macroscopically normal findings by upper endoscopy. Despite this hig

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Author

Jorge E. Romaguera; L. Jeffrey Medeiros; Frederick B. Hagemeister; Luis E. Fayad; Maria A. Rodriguez; Barbara Pro; Anas Younes; Peter McLaughlin; Andre Goy; Andreas H. Sarris; Nan H. Dang; Felipe Samaniego; H. M. Brown; Harish K. Gagneja; Fernando Cabanillas

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

2003

Language

EN

Field

Medicine (Health Sciences)