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Can I read Combination of the Sodium-glucose Cotransporter-2 Inhibitor Empagliflozin with Orlistat or Sibutramine Further Improves the Body-weight Reduction and Glucose Homeostasis of Obese Rats Fed a Cafeteria Diet on EtoBox?
Combination of the Sodium-glucose Cotransporter-2 Inhibitor Empagliflozin with Orlistat or Sibutramine Further Improves the Body-weight Reduction and Glucose Homeostasis of Obese Rats Fed a Cafeteria Diet by Steven P Vickers; Sharon Cheetham; Katie Headland; Keith Dickinson; Rolf Grempler; Eric Mayoux; Michael Mark; Thomas Klein is a Medicine article available to read on EtoBox.
What is Combination of the Sodium-glucose Cotransporter-2 Inhibitor Empagliflozin with Orlistat or Sibutramine Further Improves the Body-weight Reduction and Glucose Homeostasis of Obese Rats Fed a Cafeteria Diet about?
The present study assessed the potential of the sodium glucose-linked transporter (SGLT)-2 inhibitor empagliflozin to decrease body weight when administered alone or in combination with the clinically effective weight-loss agents orlistat and sibutramine in obese rats fed a cafeteria diet. Female Wistar rats were exposed to a cafeteria diet to induce obesity. Empagliflozin was dosed once daily (10, 30, and 60 mg/kg) for 28 days. Combination studies were subsequently performed using a submaximal empagliflozin dose (10 mg/kg) with either sibutramine or orlistat. Body weight, food, and water intake were recorded daily. The effect of drug treatment on glucose tolerance, relevant plasma parameters, and carcass composition was determined. Empagliflozin dose-dependently reduced body weight, plasma leptin, and body fat though increased urinary glucose excretion. The combination of empagliflozin and orlistat significantly reduced body weight compared to animals treated with either drug alone, and significantly improved glucose tolerance, plasma insulin, and leptin compared to vehicle-treated controls. The effect of sibutramine to improve glycemic control in an oral glucose-tolerance test wa
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- Author
- Steven P Vickers; Sharon Cheetham; Katie Headland; Keith Dickinson; Rolf Grempler; Eric Mayoux; Michael Mark; Thomas Klein
- Publisher
- Informa UK Limited
- Published
- 2014
- Language
- EN
- Field
- Medicine (Health Sciences)